February 23rd, 2023
A collaborative effort led by Dr. Anna Bigas, from the Hospital del Mar Research Institute and Josep Carreras Leukaemia Research Institute, found that the population of haematopoietic stem cells (HSC) responsible for the generation and self-renewal of the blood and immune system keeps a long-term undifferentiated state thanks to its ability to physically block its own NOTCH1 receptor through the expression of JAGGED1, a specific NOTCH activator. Authors hypothesise that the lack of this previously unknown mechanism might be the cause for the poor performance of current approaches to generate haematopoietic stem cells from induced pluripotent stem cells for regenerative medicine.
Read more sobre "Finded Notch self-inhibition keeps haematopoietic stem cells from differentiate"
February 21st, 2024
This is an international collaborative work coordinated by the Hospital del Mar Research Institut and the Hospital Clínic-IDIBAPS, published in the Journal of Neurology. This new tool may make it possible to adapt the monitoring and treatment of patients to their future evolution, opting for the most effective, but with more possible side effects in those with worse prognosis. The exact factors behind the progression of disability in multiple sclerosis, a disease with great heterogeneity, are unknown, which is why it is so important to have tools of this type.
February 14, 2024
It is a monoclonal antibody with both prophylactic and therapeutic action, isolated from blood samples of a patient infected with SARS-CoV-2 during the first wave of the pandemic. The antibody has been designed and developed by researchers from the Hospital del Mar Research Institute, the IrsiCaixa AIDS Research Institute, the National Center for Biotechnology, and the Center for Genomic Regulation. This new treatment has been patented pending commercial development. The results of the work have been published in Nature Communications journal.
Read more sobre "A new antibody manages to block all variants of SARS-CoV-2 in preclinical models"
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